In vitro primary porcine alveolar macrophage cell toxicity and African swine fever virus inactivation using five commercially supply compound disinfectants
under various condition |
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| Authors: | Machimaporn TAESUJI Khate RATTANAMAS Darsaniya PUNYADARSANIYA Thanongsak MAMOM Hoa Thi NGUYEN Sakchai RUENPHET |
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| Institution: | 1)Immunology and Virology Department, Faculty of Veterinary Medicine, Mahanakorn University of Technology, 140 Cheum-Sampan Rd. Nong Chock, Bangkok 10530, Thailand;2)Pathology Department, Faculty of Veterinary Medicine, Mahanakorn University of Technology, 140 Cheum-Sampan Rd. Nong Chock, Bangkok 10530, Thailand;3)Key Laboratory of Veterinary Biotechnology, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 100000, Vietnam |
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| Abstract: | Efficacy of African swine fever virus (ASFV) inactivation using five commercially supply compound disinfectants was evaluated under various condition. Virucidal efficacy demonstrated that products A and E could inactivate at 1:800 within 1 min for both temperatures, while products B, C and D inactivated at 1:400. However, product D could inactivate at 1:800 when the exposure time was extended to 30 min and effected only 20°C. In addition, the cytotoxicity demonstrated that products A, B, C, D and E did not significantly affect to cell at 1:51,200, 1:12,800, 1:12,800, 1:25,600 and 1:12,800 dilution, respectively. In conclusion, these disinfectants could inactivate ASFV, however, the application of these products should be performed under safety precautions to prevent cytotoxicity in humans and animals. |
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| Keywords: | African swine fever virus commercially supply compound disinfectant cytotoxicity virucidal efficacy |
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