首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Imidazenil,a new drug for the management of convulsions in organophosphate intoxication in rodents
Authors:Slawomir Rump  Teresa Gidynska  Elzbieta Galecka  Oktawiusz Antkowiak  Marek Kowalczyk
Abstract:The summary deals with the anti-convulsant and antilethal effects of a new benzodiazepine receptor partial agonist, imidazenil, in DFP intoxication. It has been demonstrated that imidazenil (2–5 mg kg?1) significantly decreases convulsion intensity, rapidly inhibits seizure patterns in brain bioelectrical activity and significantly increases the anti-lethal efficacy of atropine plus obidoxime therapy. These effects are comparable to diazepam at 5 mg kg?1. However, diazepam exhibits myorelaxant activity at therapeutic doses, which are only observed at 5–10 times the therapeutic doses of imidazenil.
Keywords:benzodiazepines  convulsions  DFP  imidazenil  organophosphate
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号