Imidazenil,a new drug for the management of convulsions in organophosphate intoxication in rodents

The summary deals with the anti-convulsant and antilethal effects of a new benzodiazepine receptor partial agonist, imidazenil, in DFP intoxication. It has been demonstrated that imidazenil (2–5 mg kg⁻¹) significantly decreases convulsion intensity, rapidly inhibits seizure patterns in brain bioelectrical activity and significantly increases the anti-lethal efficacy of atropine plus obidoxime therapy. These effects are comparable to diazepam at 5 mg kg⁻¹. However, diazepam exhibits myorelaxant activity at therapeutic doses, which are only observed at 5–10 times the therapeutic doses of imidazenil.