Cutaneous papilloma and multicentric squamous cell carcinoma in four-toed hedgehogs (Atelerix albiventris) |
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| Authors: | Naka OKUMURA Iori KOIZUMI Yuki IWATA Shion YONEYA Ryota KOBA Hirotaka KONDO Hisashi SHIBUYA |
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| Affiliation: | 1)Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa 252-0880, Japan;2)Koizumi Nest Animal Hospital, 3-24 Betto, Yahata Nishi, Kitakyushu, Fukuoka 806-0062, Japan;3)Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa 252-0880, Japan |
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| Abstract: | Skin lesions possibly caused by Papillomavirus infections in two four-toed hedgehogs are described. In case 1, there was a papillary mass on the right hind limb. Histologically, the mass was consistent with a viral papilloma. In the other case, multifocal papillary masses with erosions and ulcers were found throughout the body, mainly on the extremities. Histology showed continuative lesions composed of acanthosis, Bowenoid in situ carcinoma, and squamous cell carcinoma, with abrupt transitions between the lesions. In both cases, keratinocytes in the granular layer infrequently had features of koilocytes and intranuclear inclusion bodies, and immunohistochemical staining was positive for anti-human papillomavirus antibody. To the best of the authors’ knowledge, this is the first pathological documentation of possibly papillomavirus-associated skin lesions in four-toed hedgehogs. |
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| Keywords: | four-toed hedgehog histopathology neoplasm papillomavirus |
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