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The role of the gut in acquired resistance to Fasciola hepatica in the rat |
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| Authors: | JD Kelly NJ Campbell JK Dineen |
| Institution: | 1. Department of Veterinary Pathology, University of Sydney, Sydney, N.S.W. 2006 Australia;7. New South Wales Department of Agriculture, Veterinary Research Station, Glenfield, N.S.W. 2167 Australia;71. CSIRO Division of Animal Health, McMaster Laboratory, Sydney, N.S.W. 2037 Australia |
| Abstract: | The role of the gut in acquired resistance to Fasciola hepatica in the rat was assessed by comparison of the number of flukes recovered 4 and 10 weeks after oral or intraperitoneal challenge infection of male outbred Wistar rats previously infected by the oral or intraperitoneal routes.Previous infection given by either route generated signigicant protection against both oral and intraperitoneal challenge. The rats were resistant to Fasciola challenge in the presence of the primary infection or after its removal by anthelmintic treatment.It was concluded that passage of juvenile flukes through the gut was not essential for either the acquisition or the expression of acquired resistance to F. hepatica in the rat. |
| Keywords: | Present address and address for reprints: Victorian Department of Agriculture “Attwood” Veterinary Research Laboratory Westmeadows Vic 3047 Australia |
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