| 骨形态发生蛋白2(BMP2)基因在内蒙古绒山羊皮肤毛囊发育不同时期的表达 |
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| 引用本文： | 苏蕊,张文广,尹俊,赵珺,常子丽,李金泉. 骨形态发生蛋白2(BMP2)基因在内蒙古绒山羊皮肤毛囊发育不同时期的表达[J]. 华北农学报, 2008, 23(2): 110-113 |
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| 作者姓名： | 苏蕊 张文广 尹俊 赵珺 常子丽 李金泉 |
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| 作者单位： | 内蒙古农业大学,动物遗传育种与繁殖自治区重点实验室,内蒙古,呼和浩特,010018 |
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| 基金项目： | 国家自然科学基金 , 内蒙古自然科学基金 , 教育部春晖计划资助项目(第二批) |
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| 摘 要： | 为探讨调节内蒙古绒山羊皮肤毛囊发育相关基因及其作用机理,采用原位杂交和荧光实时定量PCR方法对BMP2基因在内蒙古绒山羊皮肤毛囊中的表达情况进行了检测,分析了其可能的作用方式。原位杂交结果表明,该基因在内蒙古绒山羊皮肤毛囊发育休止期毛干周围有强烈的表达信号,在兴盛期不表达;荧光实时定量PCR结果显示,该基因在休止期皮肤毛囊的表达量是兴盛期的27.8倍。综合上述试验结果,推测BMP2基因在毛囊发育过程中主要起抑制毛囊生长发育、维持毛囊处于休止期的作用,且可能参与新一轮的毛囊重建,因此,可将BMP2基因作为绒山羊育种过程中提高其产绒量的一个潜在的分子靶点。
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| 关 键 词： | BMP2基因 毛囊 原位杂交 荧光实时定量PCR 表达 |
| 文章编号： | 1000-7091(2008)02-0110-04 |
| 修稿时间： | 2007-10-10 |
The Expression of Inner Mongolia Cashmere Goat BMP2 in Skin and Hair Follicle at Different Development Stage |
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| SU Rui,ZHANG Wen-guang,YIN Jun,ZHAO Jun,CHANG Zi-li,LI Jin-quan. The Expression of Inner Mongolia Cashmere Goat BMP2 in Skin and Hair Follicle at Different Development Stage[J]. Acta Agriculturae Boreali-Sinica, 2008, 23(2): 110-113 |
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| Authors: | SU Rui ZHANG Wen-guang YIN Jun ZHAO Jun CHANG Zi-li LI Jin-quan |
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| Abstract: | To discuss the related genes involved in skin and hair follicle development regulated and its mechanism,the expression of BMP2 in skin and hair follicle in Inner Mongolia Cashmere goat were studied by in situ hybridization and RT-PCR.The results showed the expression of BMP2 was up-regulated in skin telogen,while it didn't expressed in anagen,and the expression of BMP2 in telogen was 27.8 times than that in anagen.These results indicated that BMP2 inhibited hair follicle development in telogen and kept hair follicle in anagen,BMP2 would be involved in new round hair forming,So,BMP2 should be a potential molecular target to improving cashmere yield in Cashmere goat breeding. |
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| Keywords: | BMP2 Hair follicle In situ hybridization Real time RT-PCR Expression |
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