香连丸抗菌作用试验研究

目的]分析香连丸药效成分（黄连、木香、吴茱萸）不同配方的抗菌作用。方法]以黄连、木香、吴茱萸为供试药物，志贺氏痢疾杆菌、福氏痢疾杆菌、宋内氏痢疾杆菌、金黄色葡萄球菌为供试菌种，研究3种药物不同配方对4种细菌的抗菌作用。结果]木香、吴茱萸、木香＋吴茱萸对4种细菌均无抗菌作用，各配方供试药液对宋内氏痢疾杆菌均无抗菌作用；黄连＋木香、吴茱萸＋木香对志贺氏痢疾杆菌和福氏痢疾杆菌的抗菌作用较黄连＋木香＋吴茱萸弱；黄连＋木香对金黄色葡萄球菌具有杀菌和抗菌作用，而黄连＋吴茱萸、黄连＋木香＋吴茱萸对金黄色葡萄球菌的抗菌作用均较弱。结论]丸剂加味香连丸的药效最佳。

Experimental Study on Antibacterial Activity of Xianglian Pill

Objective] The study was to analyze the antibacterial activities of different formulas with the effective components(Coptis chinensis,Radix aucklandiae,Evodia rutaecarpa) of Xianglian pill.Method] With C.chinensis,R.aucklandiae,E.rutaecarpa as the tested medicine and Shigella flexneri,Shengilla flexneri,Shigella sonnei,staphylococcus aureus as the tested strains,the antibacterial effects of different formulas with 3 kinds of medicine on 4 kinds of bacteria were studied.Result] R.aucklandiae,E.rutaecarpa and R.aucklandiae + E.rutaecarpa had no antibacterial activities on 4 kinds of bacteria.All tested medicine with different formulas had no antibacterial activities on S.sonnei.The antibacterial activities of C.chinensis+R.aucklandiae and E.rutaecarpa +r.Aucklandiae on S.flexneri and S.flexneri were weaker than those of C.chinensis+R.aucklandiae+ E.rutaecarpa.C.chinensis+R.aucklandiae had bactericidal and antibacterial effects on S.aureus,while the bactericidal effects of E Rutaecarpa +R aucklandiae and C chinensis+R.aucklandiae+ E.rutaecarpa were weaker.Conclusion] The pharmacological effect of mixed Xianglian pill was the best.