骨代谢相关血液生化指标的研究进展

骨代谢包括骨合成和骨吸收两个过程。受到很多因素的影响,遗传、营养、环境、性别及内分泌等都是关键调节因素。当骨吸收过程大于骨合成过程,导致骨量流失,骨密度降低,进一步发展为骨质疏松症。骨代谢过程受到内分泌的影响,很多骨代谢血液生化指标对骨病的研究起到重要作用。近年来,国内外大量的研究报道了与骨代谢相关的血液生化指标。作者着重对血钙与血磷、甲状旁腺激素、1,25-二羟维生素D₃、白细胞介素、血清总碱磷酶和骨碱磷酶等骨代谢血液生化指标对骨形成和分解的影响进行了综述。

Study on Blood Biochemical Indicators Related to Bone Metabolism

The bone metabolism includes the two processes of bone formation and bone resorption, which is influenced by many facters, hererity, nutrition, environment, gender and incretion are the key regulatory factors. When the bone resorption significantly exceeds formation; the activity of the osteoblasts cannot keep up with the activity of the osteoclasts, and then resulting in bone loss rapidly and bone density reducing. The process of bone metabolism is affected by incretion, many biochemical indexes of blood play an important role in the study of osteopathy. Many studies have reported biochemical parameters of blood related to bone metabolism. This paper summarize the effects of serum calcium and phosphorus, parathyroid hormone, 1,25-(OH)₂D₃interleukin, ALP on the bone formation and resorption.