| "头孢沙星"对小鼠的急性毒性试验 |
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| 引用本文： | 周绪正,李剑勇,张继瑜,李金善,魏小娟,牛建荣. "头孢沙星"对小鼠的急性毒性试验[J]. 动物医学进展, 2006, 27(9): 92-93 |
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| 作者姓名： | 周绪正 李剑勇 张继瑜 李金善 魏小娟 牛建荣 |
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| 作者单位： | 中国农业科学院兰州畜牧与兽药研究所新兽药重点工程实验室,甘肃兰州,730050;中国农业科学院兰州畜牧与兽药研究所新兽药重点工程实验室,甘肃兰州,730050;中国农业科学院兰州畜牧与兽药研究所新兽药重点工程实验室,甘肃兰州,730050;中国农业科学院兰州畜牧与兽药研究所新兽药重点工程实验室,甘肃兰州,730050;中国农业科学院兰州畜牧与兽药研究所新兽药重点工程实验室,甘肃兰州,730050;中国农业科学院兰州畜牧与兽药研究所新兽药重点工程实验室,甘肃兰州,730050 |
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| 摘 要： | 用150只清洁级昆明系健康小鼠,进行“头孢沙星”原药1、0 g/L制剂口服及腹腔注射急性毒性试验。结果表明,其原药LD0在10 g/kg~15 g/kg之间,LD100大于15 g/kg;其10 g/L制剂LD50=527.38 mg/kg,95%可信限范围391.84 mg/kg~696.44 mg/kg。“头孢沙星”原药属于实际无毒,10 g/L制剂按2 mg/kg临床应用安全。
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| 关 键 词： | " 头孢沙星" 急性毒性试验 小鼠 |
| 文章编号： | 1007-5038（2006）09-0092-02 |
| 收稿时间： | 2006-03-30 |
| 修稿时间： | 2006-03-30 |
Acute Toxicity Test of New Animal Antibiotic Medicine "Toubaoshaxing" in Mice |
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| ZHOU Xu-zheng,LI Jian-yong,ZHANG Ji-yu,LI Jin-shan,WEI Xiao-jua,NIU Jian-rong. Acute Toxicity Test of New Animal Antibiotic Medicine "Toubaoshaxing" in Mice[J]. Progress In Veterinary Medicine, 2006, 27(9): 92-93 |
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| Authors: | ZHOU Xu-zheng LI Jian-yong ZHANG Ji-yu LI Jin-shan WEI Xiao-jua NIU Jian-rong |
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| Affiliation: | Lanzhou Institute of Animal and Veterinary Pharmceutical Sciences, Chinese Academay of Agricultral Sciences, Key Laboratory of New Animal Medicine Project ,Ministry of Agricultrure , Lanzhou,Gansu, 730050, China |
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| Abstract: | The acute toxicity tests of "Toubaoshaxing" and 10 g/L preparation were carried out in 150 mice.The results showed that"TouBaoShaXing"maximal tolerance dose(LD_(0))varied from 10 g/kg to 15 g/kg,and absolute lethal dose(LD_(100))>15 g/kg.Median lethal dose(LD_(50))of 10 g/L preparation was(527.38 mg/kg.)The 95% certainty factor varied from 391.84 mg/kg to 696.44 mg/kg.Such a conclusion can be obtained that"Toubaoshaxing" is nontoxicity and 2 mg/kg dose of 10 g/L preparation is clinical safe. |
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| Keywords: | " Toubaoshaxing" ,acute toxicity test,mouse |
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