Dihydroisocoumarins from the Mangrove-Derived Fungus Penicillium citrinum |
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| Authors: | Guo-Lei Huang Xue-Ming Zhou Meng Bai Yu-Xin Liu Yan-Lei Zhao You-Ping Luo Yan-Yan Niu Cai-Juan Zheng Guang-Ying Chen |
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| Affiliation: | Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China; (G.-L.H.); (X.-M.Z.); (M.B.); (Y.-X.L.); (Y.-L.Z.); (Y.-P.L.); (Y.-Y.N.) |
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| Abstract: | Three new dihydroisocoumarin penicimarins G–I (1–3), together with one known dihydroisocoumarin (4) and three known meroterpenoids (5–7), were obtained from a fungus Penicillium citrinum isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of spectroscopic data. The absolute configuration of 1 was determined by the X-ray diffraction analysis using Cu Kα radiation. The absolute configurations of 2 and 3 were determined by comparison of their circular dichroism (CD) spectra with the literature. All compounds were evaluated for their antibacterial activities and cytotoxic activities. |
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| Keywords: | Penicillium citrinum metabolites dihydroisocoumarin antibacterial activity cytotoxic activity |
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