| 4,6-二氯-5-甲氧基嘧啶的合成新法 |
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| 引用本文： | 吴晓琼,傅志贤,曹国庆,杨小东.4,6-二氯-5-甲氧基嘧啶的合成新法[J].安徽农业科学,2010,38(15):7729-7730. |
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| 作者姓名： | 吴晓琼 傅志贤 曹国庆 杨小东 |
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| 作者单位： | 南京化工职业技术学院,江苏南京,210048;东南大学成贤学院,江苏南京,210088 |
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| 摘 要： | 目的]对有机中间体4,6-二氯-5-甲氧基嘧啶的合成方法进行改进。方法]以2-甲氧基-丙二酸二甲酯为原料经与氨气反应得到氨解中间体,再与甲酰胺环合成嘧啶环,最后氯化得到目标化合物4,6-二氯-5-甲氧基嘧啶。结果]产物经红外、核磁、质谱确定结构,总收率达到42%。结论]该方法条件温和,收率较高,适宜工业化生产。
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| 关 键 词： | 4 6-二氯-5-甲氧基嘧啶 磺胺多辛 除草剂 合成 |
New Method for Synthesis of 4,6-Dichloro-5-methoxypyrimidine |
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| Institution: | WU Xiao-qiong et al(Nanjing Chemical Engineering Polytechnic College,Nanjing,Jiangsu 210048) |
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| Abstract: | Objective]The research aimed to improve the synthesis method of 4,6-dichloro-5-methoxypyrimidine.Method]2-methoxy dimethyl malonate was used to prepare 4,6-dichloro-5-methoxypyrimidine by aminolysis,cyclization and chlorization.Result]The synthetic product was analyzed by IR,HNMR and MS.The overall yield was 42%.Conclusion]Synthesis method was suitable for industrial production,because of its warm condition and higher yield. |
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| Keywords: | 4 6-dichloro-5-methoxypyrimidine Sulfadoxin Phytocide Synthesis |
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