Three bianthraquinone derivatives from the mangrove endophytic fungus Alternaria sp. ZJ9-6B from the South China Sea |
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Authors: | Huang Cai-Huan Pan Jia-Hui Chen Bin Yu Miao Huang Hong-Bo Zhu Xun Lu Yong-Jun She Zhi-Gang Lin Yong-Cheng |
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Institution: | School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. |
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Abstract: | Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 μM. |
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Keywords: | endophytic fungus Alternaria sp bianthraquinone alterporriol cytotoxicity |
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