CNS activity of Alstonia macrophylla leaf extracts: an ethnomedicine of Onge of Bay Islands |
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Authors: | Chattopadhyay Debprasad Arunachalam G Ghosh Lopamudra Mandal Asit B |
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Institution: | ICMR Virus Unit Calcutta, Infectious Diseases and Beliaghata General Hospital, GB 4, 1st Floor, 57, Dr Suresh Banerjee Road, Kolkata 700 010, India. debprasadc@hotmail.com |
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Abstract: | Methanol extract at 100-200 mg/kg p.o. and major nonpolar fraction B at 50 mg/kg of Alstonia macrophylla leaves caused a significant reduction in spontaneous activity, remarkable decrease in exploratory behavioural pattern, a reduction in muscle relaxant activity and also significantly potentiated phenobarbitone sodium-induced sleeping time. The phytochemical study of crude leaf extract revealed the presence of tannin, triterpenoid, flavonoid, sterol, alkaloid and reducing sugars. Further fractionation and purification of the n-butanol part of methanol extract yielded fraction A, fraction B and fraction C along with some minor fatty acids as the major compounds. |
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Keywords: | Alstonia macrophylla CNS activity |
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