Pharmacokinetics of theophylline in swine: a potential model for human drug bioavailability studies |
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| Authors: | G. D. KORITZ D. W. A. BOURNE J. P. HUNT V. I. PRASAD R. F. BEVILL S. R. GAUTAM |
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| Affiliation: | College of Veterinary Medicine, University of Illinois, Urbana, Illinois, U.S.A;*Pharmacy Department, University of Queensland, St. Lucia, Queensland, Australia and †Biopharmaceutics Laboratory Branch, Food and Drug Administration, Washington, D.C., U.S.A |
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| Abstract: | The pharmacokinetics of theophylline in swine were investigated following die oral and intravascular administration of single doses of theophylline free base. The mean half-life of theophylline following intravascular administration was 11.0 h, and the apparent specific volume of distribution was 0.61 liter/kg. Following oral administration, theophylline in solution was absorbed quite rapidly with a bioavailability of 79%. The similarity of the pharmacokinetics of theophylline in swine and humans suggests that swine may provide a useful model for the study of the bioequivalency of theophylline dosage forms intended for human use. The pharmacokinetic characteristics of theophylline also favor its consideration for usage as a therapeutic agent in swine. |
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