Clinical outcome in dogs with nasal tumors treated with intensity-modulated radiation therapy |
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| Authors: | David W. Hunley G. Neal Mauldin Keijiro Shiomitsu Glenna E. Mauldin |
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| Affiliation: | Ocean State Veterinary Specialists, 1480 South County Trail, East Greenwich, Rhode Island 02818, USA (Hunley); Western Veterinary Specialist Centre, 1802–10th Avenue SW, Calgary, Alberta T3C 0J8 (Mauldin, Mauldin); Department of Veterinary Clinical Sciences, Louisiana State University, Skip Bertman Drive, Baton Rouge, Louisiana 70803, USA (Shiomitsu) |
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| Abstract: | Intensity-modulated radiation therapy (IMRT) is a valuable tool in human radiation oncology, but information on its use in veterinary medicine is lacking. In this study, 12 dogs with nasal tumors were treated with IMRT at a median radiation dose of 54 Gy. Patient survival times and frequency and severity of side effects on ocular structures, oral mucosa, and skin were recorded. Eight dogs (67%) had resolution of clinical signs during radiation therapy. Median overall survival time was 446 d with a 50% 1-year and a 25% 2-year survival rate. Minimal grade 2 or 3 acute skin toxicity, no grade 2 or 3 late skin toxicity, and no grade 2 or 3 toxicity to oral mucosa or the eye opposite the tumor were identified in the dogs treated with IMRT in this study. The ipsilateral eye could not be routinely spared due to its proximity to the tumor. |
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