Molecular data of UL24 homolog gene (ORF37) from Brazilian isolates of equine herpesvirus type 1 |
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| Authors: | Carvalho R F Spilki F R Cunha E M Stocco R C Arns C W |
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| Affiliation: | 1. Laboratório de Genética, Instituto Butantan, São Paulo, SP, CEP 05503-900, Brazil;2. Laboratório de Microbiologia Molecular, Instituto de Ciências da Saúde, Universidade Feevale, Novo Hamburgo, RS, CEP 93352-000, Brazil;3. Laboratório de Raiva e Encefalites Virais, Instituto Biológico de São Paulo, São Paulo, SP, CEP 04014-002, Brazil;4. Laboratório de Virologia Animal, Dep. de Microbiologia, Instituto de Biologia, Universidade de Estadual Campinas, Campinas, SP, CEP 13083 970, Brazil |
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| Abstract: | Equine herpesvirus type 1 (EHV-1) is associated with abortions, respiratory distress, and neurological disturbances in horses. The ORF37 of EHV-1 encodes a protein homolog to UL24 gene product of human herpesvirus that has been associated with neurovirulence. In the present work, ORF37 PCR fragments derived from two Brazilian EHV-1 isolates, a German isolate and an American reference strain were sequenced and characterized by molecular phylogenetic analysis. This genomic region is highly conserved an allowed to infer genetic distances between EHV-1 strains and other animal herpesvirus. |
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