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Cytotoxic effect of serotypes of Pasteurella haemolytica on sheep bronchoalveolar macrophages
Authors:A D Sutherland  W Donachie
Affiliation:1. Clinical Neurosciences and Mental Health Department, Faculty of Medicine, University of Porto, Rua Plácido Costa, 4200 Porto, Portugal;2. Psychiatry and Mental Health Clinic, São João Hospital Center, 4200 Porto, Portugal;1. Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, United States;2. Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, 1070 Arastradero Rd, suite 353, Palo Alto, CA 94304, United States;3. Department of Psychiatry, Washington University School of Medicine in St. Louis, 660 S. Euclid Ave., St. Louis, MO 63110, United States;4. College of Social Work, Ohio State University, 1947 College Road, Columbus, OH 43210, United States
Abstract:Ovine isolates of the 15 known serotypes found within the A and T biotypes of Pasteurella haemolytica were cytotoxic for sheep bronchoalveolar macrophages (BAM). Weaker toxicity for the same target cells was also expressed by non-serotypable ovine isolates of P. haemolytica. The results suggest that cytotoxicity for sheep BAM is a virulence factor common to both A and T biotypes of P. haemolytica.
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