Acute phase response in porcine reproductive and respiratory syndrome virus infection |
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Authors: | J Gmez-Laguna FJ Salguero FJ Pallars M Fernndez de Marco I Barranco JJ Cern S Martínez-Subiela K Van Reeth L Carrasco |
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Institution: | a Department of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, Cordoba University, 14014 Cordoba, Spain;b CISA-INIA, 28130 Valdeolmos, Madrid, Spain;c Department of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, Murcia University, 30100 Murcia, Spain;d Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Murcia University, 30100 Murcia, Spain;e Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium |
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Abstract: | This study was focused on the changes observed in the serum concentration of haptoglobin (Hp), C-reactive protein (CRP), serum amyloid A (SAA) and Pig-major acute protein (Pig-MAP), during experimental porcine reproductive and respiratory syndrome virus (PRRSV) infection and in their relationship with the expression of interleukin 1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). Hp and Pig-MAP serum levels were increased at 10 dpi, but CRP and SAA showed a delayed and highly variable increase. All three proinflammatory cytokines were poorly expressed, and only a mild increase in IL-1β was observed at 7 dpi. The increased expression of Hp coincided with the light enhancement observed in both IL-6 and TNF-α, and might be related with an increased expression of IL-10. The low expression of TNF-α might point to a possible mechanism of viral evasion of host-immune response. This issue and the delayed expression of CRP and SAA should be taken into account in future studies about modulation of the immune response by PRRSV infection. |
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Keywords: | Porcine reproductive and respiratory syndrome Pathogenesis Acute phase proteins Proinflammatory cytokines |
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