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| 明矾注射液在家兔体内的药物代谢动力学 | |
| 引用本文： | 蒿彩菊,杨鸣琦,刘晓强,李引乾,王发强,王爱武.明矾注射液在家兔体内的药物代谢动力学[J].西北农业学报,2009,18(1):41-44. |
| 作者姓名： | 蒿彩菊 杨鸣琦 刘晓强 李引乾 王发强 王爱武 |
| 作者单位： | 1. 西北农林科技大学,动物医学院,陕西杨凌,712100 2. 洛川县动物检疫站,陕西洛川,716000 3. 吴堡县畜牧兽医工作站,陕西吴堡,718200 |
| 基金项目： | 教育部高校科技创新工程培养基金 |
| 摘 要： | 2%的明矾注射液对氰化物中毒具有很好的治疗和解救作用,但是在家兔体内药物动力学研究未见报道.本研究证明在试验条件下明矾在家兔体内的消除半衰期(t1/2)为(2.6797±0.6042)h,体清除率(CLB)为(0.5026±0.0116)dL/(kg·h),表观分布容积(Vd)为(1.9452±0.3371)dL/kg,说明明矾注射液代谢较快,在家兔体内分布范围窄.临床用于治疗动物氰化物中毒时,宜反复给药,直至症状消失为止. |
| 关 键 词： | 药物代谢动力学 明矾注射液 家兔 |
| 收稿时间： | 2008/6/28 0:00:00 |
| 修稿时间： | 2008/9/21 0:00:00 |
The Pharmacokinetics of Alum Injection in Rabbits |
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| HAO Caiju,YANG Mingqi,LIU Xiaoqiang,LI Yinqian,WANG Faqiang and WANG Aiwu.The Pharmacokinetics of Alum Injection in Rabbits[J].Acta Agriculturae Boreali-occidentalis Sinica,2009,18(1):41-44. | |
| Authors: | HAO Caiju YANG Mingqi LIU Xiaoqiang LI Yinqian WANG Faqiang and WANG Aiwu |
| Institution: | College of Veterinary Medicinen, Northwest A & F University, Yangling Shaanxi 712100, China;College of Veterinary Medicinen, Northwest A & F University, Yangling Shaanxi 712100, China;College of Veterinary Medicinen, Northwest A & F University, Yangling Shaanxi 712100, China;College of Veterinary Medicinen, Northwest A & F University, Yangling Shaanxi 712100, China;The Animal Quarantine Station of Luochuan County, Luochuan Shaanxi 716000, China;Wubu Animal Husbandry and Veterinary Station, Wubu Shaanxi 718200, China |
| Abstract: | The 2% alum injection has good treat ment and rescue action for poisoning of cyanide,but the pharmaco kinetics of it has not been reported.This studies proved that the half life(t1/2)was (2.6797±0.6042)h,body clearance was(0.5026±0.0116)dL/(kg·h)and pparent volume of distribution was(1.9452±0.3371)dL/kg.It was indicated that the alum injection metabolized quickly and distribution was narrow in the rabbit body.It shoud administe repeatedly until symptoms disappeared in clinical treatment of animals poisoning of cyanide. |
| Keywords: | Pharmaco kinetics Aluminjection Rabbit |
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