Age Difference in Morphology and Immunohistology inthe Thymus and Spleen in Crl:CD (SD) Rats |
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Authors: | Kodama Rinya Okazaki Takanobu Sato Tamio Iwashige Shuichiro Tanigawa Yohei Fujishima Junko Moriyama Akiko Yamashita Nobuyoshi Sasaki Yuji Yoshikawa Tsuyoshi Kamimura Yasuhiro Maeda Hiroshi |
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Affiliation: | Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., 2438 Miyanoura, Kagoshima 891-1394, Japan. |
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Abstract: | We investigated chronological changes in immunohistochemical phenotyping in the thymus and spleen in Crl:CD rats up to the age of about one year. In the thymus, T cells increased markedly from 3 to 4 weeks of age. Proliferating cells also increased markedly at these points. B cells tended towards an increase with age. In the spleen, white pulp increased until 9 weeks of age and remained fairly stable thereafter. In the periarteriolar lymphoid sheath and marginal zone, T cells gradually increased until 9 weeks of age and became almost flat thereafter. In the lymph follicle, T cells increased with age. B cells tended towards an increase with age in all areas of the spleen. It was concluded that development of the thymus was most marked from 3 to 4 weeks of age and that both the thymus and spleen had matured by 9 weeks of age. |
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Keywords: | pleen thymus immunohistochemistry weaning development SD rat |
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