Assessment of the clinical and virological protection provided by a commercial inactivated bovine viral diarrhoea virus genotype 1 vaccine against a BVDV genotype 2 challenge |
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Authors: | Hamers C Couvreur B Dehan P Letellier C Fischer L Brun A J Lewalle P Michaux C Pastoret P P Kerkhofs P |
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Institution: | Department of Infectious Disease, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster 20, B-4000 Liège, Belgium. |
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Abstract: | A new genotype of bovine viral diarrhoea virus (BVDV), designated BVDV-2, has emerged in the last decade and in recent years the prevalence of BVDV-2 strains has increased. A vaccination-challenge study was carried out to determine the cross-protective efficacy of a commercial inactivated vaccine containing a BVDV-1 strain. A group of five BVDV-free calves was vaccinated twice and a second group of five calves served as negative controls. Two months after the first vaccination, all the calves were challenged intranasally with BVDV-2 strain BVD890. The clinical signs of disease, the changes in haematological variables and the level of viraemia were significantly less in the vaccinated group. |
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