Effects of somatotropin on the conceptus,uterus, and ovary during maternal recognition of pregnancy in cattle |
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| Affiliation: | 1. Monsanto Co., St. Louis, Missouri 63198, USA;2. Dairy and Poultry Science Department, USA;3. Animal Science Department, University of Florida, Gainesville, Florida 32611, USA;1. Department of Chemical Engineering, Yasouj University, Yasouj 75914-353, Iran;2. Young Researchers and Elite Club, Yasouj Branch, Islamic Azad University, Yasouj, Iran;1. Department of Veterinary Medicine, Federal University of Uberlandia (UFU), Uberlandia, MG, Brazil;2. Department of Veterinary Medicine, University of Brasilia (UnB), Brasilia, DF, Brazil;3. Embrapa Genetic Resources and Biotechnology (CENARGEN), Brasilia, DF, Brazil;1. Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil;2. Department of Obstetrics and Gynecology, Division of Human Reproduction, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil;1. Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison 53706;2. Endocrinology and Reproductive Physiology Program, University of Wisconsin-Madison, Madison 53706;3. Department of Ruminant Science, Institute of Animal Sciences, Volcani Institute, Rishon LeZion, Israel 50250;4. Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506;5. Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison 53706;1. Department of Dairy Science, University of Wisconsin-Madison, 1675 Observatory Drive, Madison, WI, United States;2. Endocrinology and Reproductive Physiology Program, University of Wisconsin-Madison, Madison, WI, United States;3. Department of Animal Science, University of São Paulo, Piracicaba, São Paulo, Brazil;4. Department of Animal Science, University of Wisconsin-Madison, 1675 Observatory Drive, Madison, WI, United States;1. The Statistical Intelligence Group LLC, Manhattan, KS, 66503, United States;2. Department of Statistics, Kansas State University, Manhattan, KS, 66506, United States;3. Zoetis, Veterinary Medicine Research and Development, Kalamazoo, MI, 49007, United States;4. Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20, 1930 Zaventem, Belgium |
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| Abstract: | Effects of recombinant bovine somatotropin (rbST) on ovarian and uterine function and the production of components of the insulin-like growth factor (IGF) system were examined during the period of maternal recognition of pregnancy in cattle. Lactating dairy cows were treated with 25 mg/d rbST (n = 8) or saline (n = 8) for 16 d after estrus. Ovaries, uteri, and conceptuses were collected on Day 17 after estrus. The length (millimeters) of the conceptus was recorded. The concentration of IGF-I and the content of IGF-binding proteins (BP) in uterine flushings were determined. Corpora lutea (CL) were weighed, and the number of follicles (⩾2 mm in diameter) were counted. Follicular fluid from the largest and second-largest follicles was assayed for the concentration of IGF-I, IGFBP, progesterone, and estradiol. The length of the conceptus and the total amount of IGF-I in uterine fluid were similar for rbST and control. Recombinant bST increased 1) the weight of the CL, 2) the number of largest follicles (10 to 15 mm in diameter), 3) the concentration of IGF-I in the follicular fluid, 4) the follicular fluid content of IGFBP of the largest estrogenic follicle, and 5) the quantity of IGFBP in uterine flushings. The concentration of progesterone in the follicular fluid tended to be increased in rbST-treated cows, whereas the concentration of estradiol was similar to that of control cows. The concentration of progesterone in plasma was similar for rbST compared with control. In conclusion, the administration of rbST in lactating dairy cows for 16 d after estrus did not alter the growth of the conceptus collected on Day 17. The greatest responses to rbST were found within the ovary, where rbST increased the weight of the CL and altered the amount of IGF-I and IGFBP in the follicular fluid. |
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