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Preparation and evaluation of danofloxacin mesylate microspheres and its pharmacokinetics in pigs |
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| Authors: | Wang Chunmei Ai Diyun Chen Cuilan Lin Heng Li Jing Shen Hongchun Yi Weixue Qi Yuanhua Wu Haigang Cao Jiyue |
| Affiliation: | 1.Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, People’s Republic of China ;2.Institute of Animal Science and Veterinary Medicine, Hubei Academy of Agricultural Sciences, Wuhan, 430070, People’s Republic of China ; |
| Abstract: | Danofloxacin mesylate gelatin microspheres (DFM-GMS) were prepared by an emulsion chemical crosslinking technique. Distribution of particle size, morphologic characteristics, drug content, and drug stability were evaluated. In-vitro study showed that the release of danofloxacin mesylate (DFM) from microspheres was much slower than from the raw material (DFM) in the release medium. Pharmacokinetic characteristics were evaluated following intramuscular injection of DFM-GMS or DFM in pigs at dosage of 2.5 mg/kg body weight. Elimination half-life (t1/2β) of the drug was 24.32 h for DFM-GMS, and 6.61 h for DFM (P? |
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