Systemic candidiasis in an apparently immunocompetent dog. |
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Authors: | M Raquel Brown Craig A Thompson Fawzi M Mohamed |
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Institution: | Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4474, USA. |
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Abstract: | Members of the family Candida spp. are ubiquitous dimorphic fungi that normally inhabit the alimentary, upper respiratory, and genital mucosae of mammals. Cell-mediated immunity appears to be an important limitation to the pathologic spread of these fungi. Prolonged immunosuppression, cytotoxic chemotherapy causing neutropenia, diabetes mellitus, long-term glucocorticoid therapy, and prolonged antimicrobial therapy have resulted in an increased incidence of both localized and disseminated candidiasis. This report describes a systemic Candida spp. infection in a dog with no obvious underlying deficiency in host resistance. Cytopathology, histopathology, transmission electron microscopy, and immunohistochemical staining were used to determine the etiology of the causative agent. |
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