Mitotane (o, DDD) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma |
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Authors: | PF BENNETT EJ NORMAN |
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Affiliation: | Companion Animal Referral Service, 37 Blackburn Rd, Mt Waverly, Victoria 3149;Division of Small Animal Clinical Studies, University of Glasgow Veterinary School, Bearsden Rd, Glasgow, G61 1QH, UK |
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Abstract: | A dog was presented with a 2 year history of polyuria and polydipsia due to pituitary-dependent hyperadrenocorticism. A low-dose dexamethasone suppression test and measurement of plasma ACTH concentration confirmed the diagnosis. Treatment was instituted with mitotane at 44 mg/kg/day and then 88 mg/kg/d without complete resolution of signs. The dog collapsed with signs consistent with liver disease and was euthanased. Necropsy revealed a phaeochromocytoma of the left adrenal medulla with extensive metastases to the liver. A chromophobe adenoma of the pars intermedia of the pituitary was found. |
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Keywords: | Pituitary-dependent hyperadrenocorticism phaeochromocytoma mitotane dog |
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