Functional involvement of Ca(2+) and Ca(2+)-activated K(+) channels in anethol-induced changes in Ca(2+) dependent excitability of F1 neurons in Helix aspersa |
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| Authors: | Ghasemi Zahra Hassanpour-Ezatti Majid Kamalinejad Mohammad Janahmadi Mahyar |
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| Institution: | a Neuroscience Research Centre and Dept. of Physiology, Medical School, Shahid Beheshti University of Medical Sciences, Evin, Tehran, Islamic Republic of Iranb Department of Biology, Faculty of Science, Shahed University, Tehran, Islamic Republic of Iranc Department of Pharmacognosy, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran |
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| Abstract: | The effects of anethol, the major component of anise oil, on the Ca2+-dependent excitability and afterhyperpolarization (AHP) in snail neurons were examined using intracellular recording. Anethol (0.5%) significantly broadened the spike, reduced the firing frequency and enhanced the AHP amplitude. In contrast, anethol (2%) significantly increased the firing frequency and decreased the AHP. Blockade of Ca2+ channels after anethol application depolarized the membrane potential and significantly reduced the firing rate. Furthermore, in the presence of anethol (0.5%) a significant decrease in the AHP was observed by Ca2+ channels blockage. Here, anethol-induced functional modification of Ca2+ and Ca2+-activated K+ channels is suggested. |
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| Keywords: | Anethol Ca2+ spike Intracellular recording Helix aspersa Ca2+ channels Ca2+-activated K+ channels |
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