Sesquiterpenes from Vladimiria souliei and their inhibitory effects on NO production |
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Authors: | Xu Jing Jin Daqin Shi Dongdong Ma Yonggang Yang Bo Zhao Peng Guo Yuanqiang |
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Affiliation: | a College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, Chinab School of Medicine, Nankai University, Tianjin 300071, Chinac College of Pharmacy, Harbin University of Commerce, Harbin 150076, Chinad Tianjin Children''s Hospital, Tianjin 300074, China |
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Abstract: | As a part of our ongoing search for plant-derived compounds that inhibit nitric oxide production, the methanol extract of the roots of Vladimiria souliei was found to show significant inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells. Bioactivity-guided isolation of the extract yielded two most active sesquiterpenes, including a new compound, named souliene A (1) and alismol (2). Their structures were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR). Two isolates showed promising inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells. |
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Keywords: | Vladimiria souliei Sesquiterpene Inhibitory effects of nitric oxide production |
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