Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway |
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Authors: | Choi Yeo-Jin Yoon Ji-Hae Cha Seon-Woo Lee Seong-Gene |
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Affiliation: | a Department of Biotechnology, Bioenergy Research Center, Chonnam National University, Gwangju 500-757, South Koreab Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-873, South Korea |
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Abstract: | Ginsenoside Rh1 has been reported to possess antiallergic and anti-inflammatory activities, but its effects on monocytes remain to be determined. Herein, we investigated the effects of Rh1 on the expression of MCP-1 and CCR2, activation of MAPK signaling, and chemotaxis of monocytes. Treatment of Rh1 decreased the levels of MCP-1 and CCR2 and the expression of VLA5 and activated β1 integrin on the cell surface, and attenuated the phosphorylation of MAPKs. Based on these results, the inhibitory effects of Rh1 on monocyte function should be regarded as a promising new anti-inflammatory response with a potential therapeutic role against inflammation-dependent diseases. |
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Keywords: | Adhesion Ginsenoside Rh1 Migration Monocyte Monocyte attractant protein-1 CCR2 |
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