Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats |
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| Authors: | Yang Lan Wang Cheng-zhang Ye Jian-zhong Li Hai-tao |
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| Affiliation: | a Institute of Chemical Industry of Forest Products, CAF, Nanjing 210042, People''s Republic of Chinab Nanjing University of Chinese Medicine, Nanjing 210046, People''s Republic of China |
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| Abstract: | The hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves were evaluated against carbon tetrachloride induced hepatic damage in Sprague-Dawley rats. The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, GBP also produced a significant and dose-dependent reversal of CCl4-diminished activity of the antioxidant enzymes and reduced CCl4-elevated level of MDA. In general, the effects of GBP were not significantly different from those of the standard drug Essentiale. |
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| Keywords: | ALT, alanine aminotransferase AST, aspartate aminotransferase ALP, alkaline phosphatase ALB, albumin TP, total protein HA, hyaluronic acid LN, laminin TG, triglyceride CHO, total cholesterol MDA, malondialdehyde. |
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