Hemodynamic alterations in dogs with shock induced by intravenous injection of heartworm extract |
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Authors: | Kitoh K Mikami C Kitagawa H Sasaki Y |
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Affiliation: | Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, Japan. |
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Abstract: | To elucidate one way of the shock mechanisms, the hemodynamic alterations were examined in 7 dogs with heartworm (HW) extract-induced shock. The first alteration observed after injection of HW extract was a decrease in right ventricular end-diastolic pressure (RVEDP). After that, left ventricular (LV) end-diastolic pressure, LV systolic pressure, and LV dp/dt fell significantly, followed by a decrease in the cardiac output of all dogs to below the detectable level (1.00 l/min). Since RVEDP depends on blood flow into the right ventricle, the decrease in RVEDP means a reduction in venous return. Therefore, this study showed that the first trigger of a decrease in blood pressure in HW extract-induced shock is the reduction in venous return. |
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