| 新烟碱类杀虫剂的结构修饰及相关作用机制研究进展 |
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| 引用本文： | 梁德胜,金淑惠,段红霞.新烟碱类杀虫剂的结构修饰及相关作用机制研究进展[J].农药学学报,2009,11(4):407-413. |
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| 作者姓名： | 梁德胜 金淑惠 段红霞 |
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| 作者单位： | 1.中国农业大学 理学院 应用化学系,北京 100193 |
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| 基金项目： | 国家自然科学基金，中国农业大学科研启动基金 |
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| 摘 要： | 新烟碱类化合物主要作用于昆虫的烟碱乙酰胆碱受体(nAChRs)。概述了新烟碱类杀虫剂的结构特征,阶段性地总结了近几年基于昆虫nAChRs结构,对新烟碱类化合物的杂环部分和功能基团进行结构修饰和改造的代表性研究成果,概要介绍了这些新化合物与昆虫nAChRs之间的相互作用机制,有助于进一步探索和开发高活性的新烟碱类化合物。
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| 关 键 词： | 新烟碱 烟碱乙酰胆碱受体 结构修饰 作用机制 |
| 收稿时间： | 2009/6/23 0:00:00 |
Advances in Study of Structural Modification and Modesof Action of Neonicotinoids |
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| LIANG De-sheng,JIN Shu-hui and DUAN Hong-xia.Advances in Study of Structural Modification and Modesof Action of Neonicotinoids[J].Chinese Journal of Pesticide Science,2009,11(4):407-413. |
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| Authors: | LIANG De-sheng JIN Shu-hui and DUAN Hong-xia |
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| Institution: | 1.Department of Applied Chemistry,College of Science,China Agricultural University,Beijing 100193,China |
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| Abstract: | Neonicotinoids act mainly on insect nicotinic acetylcholine receptors (nAChRs).The structure character of neonicotinoids is described and the typical advances on structural modification for heterocyclic and pharmacophore groups of neonicotinoids based on insect nAChRs structure in recent years are reviewed.In addition,the modes of action between new compound and insect nAChRs are summaried.It is believed that all of them would provide a theoretical help for exploring novel nicotinic compound with high activity. |
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| Keywords: | neonicotinoids nicotinic acetylcholine receptors (nAChRs) structural modification mode of action |
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