| 昆仑山小花棘豆生物碱提取及其对小鼠毒性试验 |
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| 引用本文： | 赵金香,年伟,陶大勇,张成龙,陈瑛. 昆仑山小花棘豆生物碱提取及其对小鼠毒性试验[J]. 中兽医医药杂志, 2013, 32(1): 30-32 |
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| 作者姓名： | 赵金香 年伟 陶大勇 张成龙 陈瑛 |
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| 作者单位： | 塔里木大学动物科学学院,新疆阿拉尔,843300 |
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| 基金项目： | 国家自然科学基金(项目批准号:31160520) |
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| 摘 要： | 为进一步研究小花棘豆有毒成分提取方法及毒性作用,将昆仑山小花棘豆全草粉用不同浓度乙醇提取,以提取温度、超声时间和料液比等因素进行正交试验,考察对小花棘豆活性成分提取率的影响,并通过毒性试验对小花棘豆生物碱毒性进行评价。结果表明,提取温度、超声时间、料液比对小花棘豆生物碱提取率影响不显著。小花棘豆生物碱是其主要毒性成分,按1∶10浓度注射小花棘豆生物碱约3 mL可致小鼠死亡。
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| 关 键 词： | 小花棘豆 生物碱 毒性 |
Extraction of alkaloid from Oxytropis glabra DC. and test on its toxicity in mice |
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| ZHAO Jin-xiang , NIAN Wei , TAO Da-yong , ZHANG Cheng-long , CHEN Ying. Extraction of alkaloid from Oxytropis glabra DC. and test on its toxicity in mice[J]. Journal of Traditional Chinese Veterinary Medicine, 2013, 32(1): 30-32 |
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| Authors: | ZHAO Jin-xiang NIAN Wei TAO Da-yong ZHANG Cheng-long CHEN Ying |
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| Affiliation: | (College of Animal Science,Tarim University,Alar Xinjiang 843300,China) |
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| Abstract: | Orthogonal design was adopted to extract alkaloid from Oxytropis glabra DC.based on ethanol concentration,extracting temperature,ultrasonic processing time and solid-liquid ratio.Then its toxicity in mice was studied.The results showed that the four factors had no significant effect on the yield of alkaloid,which was the main toxic contents of Oxytropis glabra DC..Mice were killed after injected with 3 mL of the alkaloid with the concentration of 1∶10. |
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| Keywords: | Oxytropis glabra DC. alkaloid toxicity |
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