| 地锦草抗宫颈癌活性研究 |
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| 引用本文： | 玮罕,耿果霞,李青旺,李健,田永芝.地锦草抗宫颈癌活性研究[J].中国畜牧兽医,2010,37(3):192-193. |
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| 作者姓名： | 玮罕 耿果霞 李青旺 李健 田永芝 |
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| 作者单位： | （1.西北农林科技大学动物科技学院， 杨凌 712100； 2.燕山大学环化学院生物工程系， 秦皇岛 066004；3.新疆石河子大学动物科技学院， 石河子 832003） |
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| 摘 要： | 地锦草临床上多用于治疗菌痢、肠炎、病毒性肝炎、咳血、尿血、便血等。本试验通过建立小鼠U14宫颈癌模型,利用水煎法得到水提物,根据抑瘤率和对突变型p53蛋白表达的影响来研究地锦草水提物体内抗宫颈癌活性。结果表明,地锦草水提物能够显著抑制肿瘤生长,同时能使肿瘤组织的突变型p53蛋白的表达量显著下调。这可能是地锦草水提物抗肿瘤作用的潜在机制。
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| 关 键 词： | 地锦草 U14宫颈癌 p53蛋白 |
Study on Anti-cervical Cancer Activity of Euphorbia Humifusa |
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| WEI Han,GENG Guo-xia,LI Qing-wang,LI Jian,TIAN Yong-zhi.Study on Anti-cervical Cancer Activity of Euphorbia Humifusa[J].China Animal Husbandry & Veterinary Medicine,2010,37(3):192-193. |
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| Authors: | WEI Han GENG Guo-xia LI Qing-wang LI Jian TIAN Yong-zhi |
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| Institution: | (1.College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China; 2.Department of Biological Engineering, College of Environment & Chemical Engineering, Yanshan University, Qinhuangdao 066004, China;3.Department of Animal Science and Technology, Shihezi University, Shihezi 832003, China) |
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| Abstract: | Euphorbia humifusa is always used to cure bacillary dysentery,enteritis,virus hepatitis,coughing up blood,blood urine,blood feces.This study using cervical cancer-bearing mice models investigated the anti-cervical activity of Euphorbia humifusa which was extracted by decoction according to tumor inhibition rate and the effect on expression of mutant p53 protein.It was obvious that the aqueous extract of Euphorbia humifusa could inhibit growth of tumor and significantly down regulate the expression of mutant... |
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| Keywords: | Euphorbia humifusa U14 cervical cancer p53 |
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