Complete atrioventricular canal defect in a foal: Clinical and pathological features |
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Authors: | Marc S. Kraus DVM, Dipl ACVIM , Romain Pariaut DMV, Ana Alcaraz DVM, PhD, Dipl ACVP, Anna R.M. Gelzer Dr med vet, Dipl ACVIM , Dipl ECVIM-CA , Nina Malik DVM, Shari Renaud-Farrell VT, Mary Ellen Charter VT, Philip R. Fox DVM, MS, Dipl ACVIM , Dipl ECVIM-CA ,N. Sydney Moï se DVM, MS, Dipl ACVIM |
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Affiliation: | aSection of Cardiology, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA;bSection of Pathology, Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA;cCaspary Institute, The Animal Medical Center, Section of Cardiology, Bobst Hospital of The Animal Medical Center, NY 10021, USA |
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Abstract: | Atrioventricular (AV) canal defects comprise a rare category of congenital heart disease associated with abnormal development of the endocardial cushions. These anomalies include a broad spectrum of lesions involving the atrial septum primum, the inlet portion of the ventricular septum, and the atrioventricular valves. In severe cases heart failure may result. The present report describes cardiopulmonary findings in a six-week-old, female Thoroughbred foal with persistent tachypnea and tachycardia since birth. Clinical, echocardiographic, cardiac catheterization, and pathologic findings were compatible with complete AV canal defect with bi-directional shunting, congestive heart failure, and pulmonary hypertension. Gross cardiac pathologic findings included a large atrioventricular septal defect, a common atriovalvular orifice, five atrioventricular leaflets, with two free-floating bridging leaflets. Histopathologic lesions in the lung included hypertrophy of the pulmonary arteriolar walls due to thickening of the tunica media. This represents a well documented case of complete endocardial cushion defect with anomalous development of the atrioventricular valves and resultant pulmonary hypertension and heart failure. |
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Keywords: | Complete atrioventricular canal defect Endocardial cushion defect Pulmonary hypertension Pathology Equine |
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