Recurrence analysis of intraoperative acridine orange-photodynamic therapy for dogs with intranasal tumors |
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| Authors: | Takuya Maruo Yasuhiro Fukuyama Yuta Nishiyama Yuki Nemoto Eiichi Kanai Shinpei Kawarai Hideki Kayanuma Kensuke Orito |
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| Affiliation: | Laboratory of Veterinary Radiology (Maruo, Kayanuma); Veterinary Teaching Hospital (Fukuyama, Nishiyama, Nemoto, Kawarai); Laboratory of Small Animal Surgery (Kanai); Laboratory of Veterinary Physiology II (Orito); School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan |
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| Abstract: | Intraoperative acridine orange-photodynamic therapy (AO-PDT) and cribriform plate irradiation are used to treat canine intranasal tumors. The purpose of this study was to evaluate the effects of AO-PDT on intranasal tumors and the recurrence rate of tumors after this treatment. Treatments with AO-PDT were performed on 38 dogs through a narrow window of the dorsal nasal cavity. The median progression-free interval was 12 mo and recurrence was detected in 21 dogs. Based on computed tomography, recurrence in 16 dogs was biased to the following areas: lateral (n = 10), medial (n = 2), ventral (n = 0), rostral (n = 0), and caudal (n = 8). Side effects were mild and included subcutaneous emphysema and rhinitis. The median survival time was 24 mo. Although AO-PDT with cribriform irradiation is an effective treatment for intranasal tumors, AO-PDT techniques should be improved to treat the nasal cavity more uniformly and thoroughly. |
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