Comparison of the alkalizing abilities between 1.35% sodium bicarbonate
solutions with and without dextrose in healthy calves |
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| Authors: | Kaoru SATO Kenji TSUKANO Mayumi KURATA Tadaharu AJITO Haruyuki HIRATA Kazuyuki SUZUKI |
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| Affiliation: | 1)Large Animal Technical Services Team, Nippon Zenyaku Kogyo Tokyo Branch Office, Tokyo, Japan;2)School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan;3)Hokkaido Agricultural Mutual Aid Association, Hokkaido, Japan;4)Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan |
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| Abstract: | The present study aimed to clarify the alkalizing ability of 1.35% isotonic sodium bicarbonate solution (ISBS), which did not contain dextrose, compared with that of 1.35% isotonic bicarbonate sodium solution containing 4.03% dextrose (ISBD) in healthy calves. The calves were intravenously administered with 20.7 mL/kg of the solutions for 30 min as the volume required to correct base deficit of 10 mM. ISBS increased the blood pH, HCO3−, and base excess from 7.44 ± 0.02, 29.6 ± 1.9 mM, and 5.3 ± 2.1 mM to 7.49 ± 0.02, 36.9 ± 2.3 mM, and 13.5 ± 2.6 mM respectively (P<0.05). These factors for the ISBD group increased from 7.41 ± 0.02, 29.0 ± 1.1 mM, and 4.5 ± 1.3 mM to 7.43 ± 0.02, 33.5 ± 1.9 mM, and 9.5 ± 1.7 mM (P<0.05), respectively. Furthermore, in the ISBD group, the relative plasma volume and blood glucose level increased while the K+ level decreased, which did not occur in the ISBS group. Therefore, the results revealed that ISBS had better alkalizing ability in calves than ISBD. |
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| Keywords: | calf dextrose hyperkalemia isotonic sodium bicarbonate metabolic acidosis |
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