Mono- and Dimeric Xanthones with Anti-Glioma and Anti-Inflammatory Activities from the Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722 |
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| Authors: | Senhua Chen Heng Guo Minghua Jiang Qilin Wu Jing Li Hongjie Shen Lan Liu |
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| Affiliation: | 1.School of Marine Sciences, Sun Yat-sen University, Zhuhai 519082, China; (S.C.); (H.G.); (M.J.); (Q.W.); (J.L.);2.Southern Laboratory of Ocean Science and Engineering, Zhuhai 519082, China;3.Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Zhuhai 519082, China;4.Pearl River Estuary Marine Ecosystem Research Station, Ministry of Education, Zhuhai 519082, China |
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| Abstract: | Seven new xanthones, diaporthones A−G (1−7), together with 13 known analogues, including five mono- (8−14) and six dimeric xanthones (15−20), were obtained from the ascidian-derived fungus Diaporthe sp. SYSU-MS4722. Their planar structures were established by extensive spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HR-ESIMS). The absolute configurations of 1−7 were clearly identified by X-ray crystallographic analysis and calculation of the ECD Spectra. Compounds 15−20 showed significant anti-inflammatory activity with IC50 values between 6.3 and 8.0 μM. In addition, dimeric xanthones (15−20) showed selective cytotoxicity against T98G cell lines with IC50 values ranging from 19.5 to 78.0 μM. |
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| Keywords: | xanthones ascidian-derived fungus Diaporthe sp. anti-glioma activity |
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