Antibacterial Activity of 9-Octadecanoic Acid-Hexadecanoic Acid-Tetrahydrofuran-3,4-Diyl Ester from Neem Oil |
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| Authors: | PU Zhong-hui ZHANG Yu-qun YIN Zhong-qiong XU Jiao JIA Ren-yong LU Yang YANG Fan |
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| Institution: | 1. College of Animal Medicine, Sichuan Agricultural University, Ya''an 625014, P.R.China;2. Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Ya''an 625014, P.R.China;3. State Key Laboratory of Veterinary Etiologocal Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046 P.R.China;4. Key Laboratory of Herb Medicine, Veterinary Chemical Medicine and Safety Evaluation, Ministry of Agriculture/College of Veterinary Medicine, China Agricultural University, Beijing 100193, P.R.China;1. Department of Botany, Arulmigu Palaniandavar Arts College for Women, Cinnakalayamputhur, Palani, Tamil Nadu, India;2. Computational Phytochemistry Lab, PG and Research Department of Botany, AVVM Sri Pushpam College (Autonomous) Poondi, Thanjavur (Dist), Tamil Nadu, India;3. Department of Nanotechnology, Noorul Islam Centre for Higher Education, Kumaracoil, Kanyakumari district, 629180, Tamil Nadu, India;1. Department of Biotechnology, College of Biological and Chemical Engineering, Addis Ababa Science and Technology University, Addis Ababa 16417, Ethiopia;2. Department of Biotechnology, School of Life Sciences, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu 641021, India;1. Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, 110062, India;2. Department of Research and Developments, Herbalfarm Health Care Private Limited, New Delhi, 110020, India;3. Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, 110062, India;4. Faculty of Pharmacy, Integral University, Lucknow, 226026, India;5. Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia;6. Department of Pharmacognosy, Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia;7. Department of Clinical Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia;1. Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, Shaanxi, China;2. Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, Shaanxi Normal University, Shaanxi, China;1. Department of Chemical Sciences, Redeemer''s University, Private Mail Bag 3005, Redemption Camp, Mowe, Ogun State, Nigeria;2. Department of Food Technology, Yaba College of Technology, Yaba, Lagos, Nigeria |
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| Abstract: | The 9-octadecanoic acid-hexadecanoic acid-tetrahydrofuran-3,4-diyl ester from neem oil was investigated for antibacterial activity against three bacterial strains viz.,Staphylococcus aureus ATCC No.25923,Escherichia coli ATCC No.44102 and Salmonella sp.ATCC No.50 041 in vitro.The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of the 9-octadecanoic acid-hexadecanoic acid-tetrahydrofuran-3,4-diyl ester were determined by using the broth microdilution dilution (BMD) method at different concentrations ranging from 20 to 0.625 mg mL-1 Its time-inhibition curve against E.coli was also tested and showed that the MIC values for the bacterial strains S.aureus,E.coli and Salmonella sp.were 20,5 and 10 mg mL-1,respectively.Its MBC values were 20,20 and 10 mg rnL-1,respectively.The antibacterial activity of 9-octadecanoic acid-hexadecanoic acid-tetrahydrofuran-3,4-diyl ester against three strain tested showed the relationship with time and concentration. |
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| Keywords: | Azadirachta indica A Juss neem oil MIC MBC time-inhibition curve 9-octadecanoic acid-hexadecanoic acid-tetrahydro furan-3 4-diyl ester |
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