|
|||||
|
|
Surface modification of silk fibroin nanofibrous mat with dextran for wound dressing |
|
| Authors: | Moo Kon Kim Hyo Won Kwak Hyung Hwan Kim Tae Rin Kwon So Young Kim Beom Joon Kim Young Hwan Park Ki Hoon Lee |
| Affiliation: | 1. Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, 151-921, Korea 2. Major in Biomedical Science, Department of Medicine, Graduate school, Chung-Ang University, Seoul, 156-755, Korea 3. Department of Dermatology, Chung-Ang University College of Medicine, Seoul, 156-755, Korea 4. Center for Food and Bioconvergence, Seoul National University, Seoul, 151-921, Korea 5. Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Korea |
| Abstract: | In this study, we examined the effects of a dextran-modified silk fibroin nanofibrous mat (D-SFNM) on wound healing. To increase the hydrophilicity of silk fibroin (SF), the SF nanofibrous mat (SFNM) was modified with oxidized dextran. The D-SFNM absorbed water faster than the SFNM, and the swelling ratio was increased by approximately 80 % compared with the SFNM. An in vitro cell (NIH3T3) test revealed that fewer cells attached to the D-SFNM than the SFNM, but the proliferation of cells was not significantly affected by the presence of dextran. An in vivo wound healing test with mice indicated that the D-SFNM resulted in a good wound recovery effect similar to a commercial wound dressing material. The increased hydrophilicity of the D-SFNM might balance the moist environment at the wound site, which improves the wound healing compared with the SFNM. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |