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Tumor-promoting phorbol esters stimulate hematopoietic colony formation in vitro |
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| Authors: | R K Stuart J A Hamilton |
| Abstract: | Tumor-promoting phorbol esters stimulated mouse bone marrow cells to form myeloid colonies in agar cultures without added colony-stimulating factors. The colony-stimulating ability of various phorbol esters correlated well with their ability to promote skin tumors in vivo. These results suggest that phorbol esters mimic the action of specific colony-stimulating factors that regulate growth. |
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