肺炎支原体感染对大鼠免疫功能和一些生化指标的影响

采用滴鼻法建立大鼠肺炎支原体感染模型 ,并对其体液免疫和细胞免疫功能进行了检测。与正常对照组相比 ,感染组大鼠血清中IgG、IgM明显降低 ,C3补体增加 ;血清中IL 2、IL 6降低 ,TNF α增高 ;全血中CD+ 8增加 ,CD+ 4/CD+ 8比值降低 ;血浆中NO、MDA含量增加 ,GSH Px活性增加。结果表明 ,细胞因子和免疫球蛋白的紊乱导致机体体液免疫和细胞免疫功能的低下 ,并诱发肺部广泛的炎症反应 ,提示它们在肺炎支原体感染的发病机制及肺外并发症的发生中起重要作用。

Immunocompetence function in rats infected with mycoplasma pneumoniae

A rat model of mycoplasmal pneumonia was developed in repeated intranasal infectious routes and then the humoral and cellular immunocompetences were detected.Compared with the normal control group,the levels of serum IgG,IgM and IL-2,IL-6 in the rats with mycoplasma pneumoniae(MP) decreased,the complement C_3 and TNF-α were higher,the ratio of CD~+_4/CD~+_8 decreased significantly,the levels of plasma NO,MDA were higher and GSH-Px was lower.All the results showed that there was an imbalance of cytokine and immunoglobulin in the rats with MP which resulted in depression of a series of cell-immune and humoral-immune response and induction of wide inflammation in lung,which may play an important role in the pathogenesis of MP.