| 湖北青砖茶对IBS-D模型大鼠肠道敏感性的影响 |
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| 引用本文： | 李世刚,郑倩倩,何建刚,肖长义,柳蔚,王慧,刘锦程.湖北青砖茶对IBS-D模型大鼠肠道敏感性的影响[J].茶叶科学,2016(3):245-249. |
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| 作者姓名： | 李世刚 郑倩倩 何建刚 肖长义 柳蔚 王慧 刘锦程 |
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| 作者单位： | 1. 湖北长盛川青砖茶研究所，湖北 宜昌 443002; 三峡大学医学院，湖北 宜昌 443002;2. 三峡大学医学院,湖北 宜昌,443002;3. 湖北长盛川青砖茶研究所,湖北 宜昌,443002;4. 湖北长盛川青砖茶研究所，湖北 宜昌 443002; 三峡大学生物工程与制药工程学院，湖北 宜昌 443002 |
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| 摘 要： | 研究了湖北青砖茶对腹泻型肠易激综合征(IBS-D)模型大鼠肠道的影响。结果表明,与正常组相比,模型组的痛阈值明显降低,血清中炎症因子前列腺素2(PGE2)、肿瘤坏死因子(TNF-α)、类胰蛋白酶的含量明显增加;与模型组比较,湖北青砖茶低剂量组、高剂量组能够显著升高痛阈值,而血清中炎症因子PGE2、TNF-α、类胰蛋白酶的含量显著降低,且具有剂量依赖性。由此表明湖北青砖茶可降低IBS-D模型大鼠的肠道敏感性,其作用机制可能与血清中PGE2、TNF-α和类胰蛋白酶含量的降低有关。
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| 关 键 词： | 湖北青砖茶 IBS-D 肠道敏感性 结肠组织 炎症因子 |
The Effects of Hubei Qingzhuan Tea on Intestinal Sensitivity in IBS-D Mouse Model |
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| LI Shigang,ZHENG Qianqian,HE Jiangang,XIAO Changyi,LIU Wei,WANG Hui,LIU Jincheng.The Effects of Hubei Qingzhuan Tea on Intestinal Sensitivity in IBS-D Mouse Model[J].Journal of Tea Science,2016(3):245-249. |
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| Authors: | LI Shigang ZHENG Qianqian HE Jiangang XIAO Changyi LIU Wei WANG Hui LIU Jincheng |
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| Abstract: | The effects of Hubei Qingzhuan tea on intestinal sensitivity in IBS-D mouse model were investigated. The results showed, compared with the normal group, the control group had a significant reduction in the pain threshold, and marked increase in the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase. Compared with the control group, both the low and high dose of Qingzhuan tea significantly increased the pain threshold and markedly decreased the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase by a dose dependent manner. It is concluded that Qingzhuan tea could significantly decrease the intestinal sensitivity of IBS-D mice, which might be related to the inhibition of serum PGE2, TNF-alpha and tryptase levels. |
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| Keywords: | Hubei Qingzhuan tea IBS-D visceral sensitivity colon tissue inflammatory cytokines |
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