Distribution of S-100 positive dendritic cells in bovine pharynx, tonsils, and retropharyngeal lymph nodes |
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Authors: | Jiaxin Wang Haixia Bian Wei Shi Zhanjun Lu |
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Institution: | (1) Institute for Laboratory Animal Science, Hebei Medical University, Shijiazhuang, 051000, China;(2) Department of Immunology and Cell Biology, College of Veterinary Medicine, Agricultural University of Hebei, Baoding, 071001, China |
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Abstract: | Dendritic cells (DCs) are professional antigen-presenting cells. However, the distribution of bovine DCs in the pharynx, tonsil,
and retropharyngeal lymph nodes has not yet been documented. To address this issue, immunohistochemistry was conducted using
S-100 protein as a marker for DCs. It was observed that S-100 positive Langerhans cells (LCs) were primarily found in the
basal layer of the pharyngeal epithelium. Some DCs were found in the outer layer of the epithelium and their dendrites extended
out towards the epithelial surface. In the tonsil, S-100 positive DCs were found either in follicular germinal centers or
in the T-cell areas. It is worth noting that the S-100 positive DCs were not only distributed in the cortex, but also in the
medulla of bovine retropharyngeal lymph nodes. The distribution patterns of bovine DCs in the pharynx, tonsil, and retropharyngeal
lymph nodes have an important implication for our understanding of the interaction between pathogens and host. |
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Keywords: | dendritic cells bovine pharynx lymph node tonsil immunohistochemistry |
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