| 生物抗菌肽的研究现状 |
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| 引用本文： | 赵爱珍,韩文瑜,孟宪荣,刘霞,曾林. 生物抗菌肽的研究现状[J]. 动物医学进展, 2005, 26(11): 8-11 |
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| 作者姓名： | 赵爱珍 韩文瑜 孟宪荣 刘霞 曾林 |
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| 作者单位： | 吉林大学畜牧兽医学院,吉林长春,130062;济南军区总医院动物实验中心,山东济南,250031;吉林大学畜牧兽医学院,吉林长春,130062;济南军区总医院动物实验中心,山东济南,250031 |
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| 摘 要： | 抗菌肽为生物机体内天然免疫系统的重要组成部分,具有抗细菌、抗病毒、抗真菌等多种生物学活性。抗菌肽或者类似物主要通过使细胞膜通透性增大而抑制或者杀死靶细胞,具有作为新型抗生素和食品添加剂的潜在应用前景。不同抗菌肽之间、抗菌肽与传统抗生素具有协同效应,这在一定程度上拓宽了抗菌肽的应用范围。
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| 关 键 词： | 抗菌肽 生物学活性 作用机理 协同效应 |
| 文章编号： | 1007-5038（2005）11-0008-04 |
| 收稿时间： | 2005-08-15 |
| 修稿时间： | 2005-08-15 |
Current Study on Antimicrobial Peptides |
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| ZHAO Ai-zhen,HAN Wen-yu,MENG Xian-rong,LIU Xia,ZENG Lin. Current Study on Antimicrobial Peptides[J]. Progress In Veterinary Medicine, 2005, 26(11): 8-11 |
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| Authors: | ZHAO Ai-zhen HAN Wen-yu MENG Xian-rong LIU Xia ZENG Lin |
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| Affiliation: | 1. College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin , 130062, China ;2. Animal Experiment Centre, J inan Military Command General Hospital, J inan , Shandong , 250031 ,China |
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| Abstract: | Antimicrobial peptides serve as the main components of innate immune system in various cellular life forms,possessing a broad range of biological activity against bacteria,virus and fungi.Antimicrobial peptides or their analogs mainly exert bactericidal or bacteriostatic mode of action on target cells by increasing membrane permeability,and have potential application as novel drugs and food biopreservatives.Synergy exists between different antimicrobial peptides or peptides and conventional antibiotics,which broaden the target-cell range of these peptides. |
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| Keywords: | antimicrobial peptide biological activity mode of action synergy |
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