卵泡抑素的生物学作用及其机制的研究

卵泡抑素又名ＦＳＨ抑制蛋白（ＦＳＨ ｓｕｐｐｒｅｓｓｉｎｇ ｐｒｏｔｅｉｎ，ＦＳＰ），是一种单链糖蛋白，有多种形式。作为Ａｃｔｉｖｉｎ的结合蛋白，它可以通过Ａｃｔｉｖｉｎ／ＦＳＰ系统来调节动物的生殖活动。近年来的实验表明，ＦＳＰ可以通过其作用系统，在生殖系统以外的器官例如肝、肾、胰、骨骼、皮肤等器官和组织中起作用。ＦＳＰ在细胞表面有肝素结合区，这有利于发挥其生物学作用。ＦＳＰ更可能是通过旁分泌或自

Studies on Biological Function and Mechanism of Follistatin

Follistatin or FSH suppressing protein(FSP),a family of single chain glucoprotein,generated by differential splicimg and proteolytic processing,has function in such system as liver pancreatic islets,kidney,bone,skin and brain,it has been suggested that FSP function in a paracrine or autocrine way by binding to the activin.The binding of FSP to the cell surface proteglycans appears to umderlie the ability of follistatin to reguiate the biological actions of activin,particularly at the local level.