Pharmacokinetics of tinidazole in the horse |
| |
Authors: | S PYÖRÄLÄ T KOTILAINEN P SILVENNOINEN U HÄNNINEN M MERO L KAARTINEN |
| |
Institution: | Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Hautj?rvi, Finland. |
| |
Abstract: | Serum tinidazole concentrations were monitored in five clinically healthy adult horses after intravenous (i.v.) and oral administration of the drug (15 mg/kg and 25 mg/kg, respectively). After i.v. administration, the mean residence time was 7.0 h, the elimination half-life 5.2 h and the body clearance rate 1.6 ml/min/kg. The distribution volume was found to be 660 ml/kg. After oral administration, the mean residence time was 8.5 h, the absorption half-life 1.1 h and the bioavailability essentially 100%. In view of the in-vitro sensitivities of various anaerobic bacteria, a dosage of 10-15 mg/kg of tinidazole, orally, at 12-h intervals, can be recommended for the treatment of anaerobic infections in horses. |
| |
Keywords: | |
|
|