Development of canine nephrotic syndrome model |
| |
Authors: | Choi Eun-Wha Lee Chang-Woo |
| |
Institution: | Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University, Kwanak-gu, Korea. |
| |
Abstract: | To develop an experimental animal model for immune-mediated glomerulonephritis and nephrotic syndrome, nine healthy dogs were sensitized by intravenous injection with 1 microg of endotoxin and 5 mg of native bovine serum albumin. After 1 week, 120 mg of cationized bovine serum albumin was injected intravenously 5 times a week. Among nine dogs, five dogs were confirmed as having developed glomerulonephritis and nephrotic syndrome by increase of urine protein-to-creatinine ratio (>1.0), hypoalbuminemia (<1.5 g/dl), hypercholesterolemia (>240 mg/dl), and edema. This model should be useful for studying immune-mediated glomerulonephritis and nephrotic syndrome. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|