Effect of Preoperative Erythromycin or Dexamethasone/Vitamin C on Postoperative Abomasal Emptying Rate in Dairy Cows Undergoing Surgical Correction of Abomasal Volvulus |
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Authors: | THOMAS WITTEK Dr habil Diplomate ECBHM KATJA TISCHER DVM IMKE KÖRNER Dr Med Vet TATJANA SATTLER Dr Med Vet PETER D CONSTABLE BVSc PhD Diplomate ACVIM MANFRED FÜRLL Dr habil Diplomate ECBHM |
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Institution: | Medizinische Tierklinik, Universität Leipzig, Germany;and;Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN |
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Abstract: | Objective— To determine the effects of preoperative erythromycin or combined dexamethasone/vitamin C treatment on postoperative abomasal emptying rate in cows undergoing surgical correction of abomasal volvulus (AV). Study Design— Prospective, controlled, clinical study using a convenience sample. Animals— Lactating Holstein–Friesian cows (n=45) with AV were alternately assigned to 3 groups (n=15): group C: untreated (control); group E: erythromycin (10 mg/kg intramuscularly IM]); group D: dexamethasone (0.02 mg/kg intravenously IV]) and vitamin C (10 mg/kg IV). Methods— Drugs were administered 1 hour before surgical correction of AV. d -xylose solution (50%, 0.5 g/kg body weight) was injected into the abomasal lumen during surgery. Jugular venous blood samples for determination of serum d -xylose concentration were periodically obtained. Time to maximal serum d -xylose concentration (Tmax-model) was pharmacokinetically determined. Results— Abomasal emptying rate was significantly ( P <0.05) faster in group E (Tmax-model=182±69 min; mean±SD) than in group C cows (Tmax-model=237±64 min). Abomasal emptying rate was similar in group D (Tmax-model=196±47 min) and group C. Both treatments improved postoperative milk yield within 1 day after surgery. Conclusion— Preoperative injection of erythromycin (10 mg/kg IM) is an effective method for ameliorating postoperative abomasal hypomotility in cows with AV. Clinical Relevance— Parenteral erythromycin can be recommended for preoperative treatment of cows with AV. |
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