| 甲磺酸单诺沙星脂质体包封率的测定 |
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| 引用本文： | 柳颖,李继昌,潘晓影,张卓. 甲磺酸单诺沙星脂质体包封率的测定[J]. 东北农业大学学报, 2008, 39(5): 98-100 |
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| 作者姓名： | 柳颖 李继昌 潘晓影 张卓 |
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| 作者单位： | 东北农业大学动物医学院,哈尔滨,150030 |
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| 基金项目： | 哈尔滨市科技创新人才研究专项资助项目 |
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| 摘 要： | 利用反透析-反相高效液相色谱法测定甲磺酸单诺沙星脂质体包封率。结果表明,该法能使甲磺酸单诺沙星与辅料及溶剂得到良好分离,甲磺酸单诺沙星在0.01～10μg.mL-1浓度范围内线性关系良好(r=0.9997,n=3),该法准确简单,重复性好,可用于甲磺酸单诺沙星脂质体包封率的测定。
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| 关 键 词： | 甲磺酸单诺沙星 脂质体 包封率 |
Determination of entrapment efficiency of the danofloxacin mesylate liposomes |
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| LIU Ying,LI Jichang,PAN Xiaoying,ZHANG Zhuo. Determination of entrapment efficiency of the danofloxacin mesylate liposomes[J]. Journal of Northeast Agricultural University, 2008, 39(5): 98-100 |
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| Authors: | LIU Ying LI Jichang PAN Xiaoying ZHANG Zhuo |
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| Abstract: | Reverse dialysis with RP-HPLC method was established to determine the entrapment efficiency of liposome. Regression analysis of the peak area against danofloxacin concentration showed a good straight line fit over the range of 0.01 and 10 μg·mL-1. This method is accurate, simple and has a good reappearance. It can be used to examine the entrapment efficiency of danofloxacin mesylate liposomes. |
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| Keywords: | danofloxacin mesylate liposomes entrapment efficiency |
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