| 有机锌试剂1,4-加成反应合成前列腺素E1甲酯的研究 |
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| 引用本文： | 马养民,傅建熙.有机锌试剂1,4-加成反应合成前列腺素E1甲酯的研究[J].西北农林科技大学学报(社会科学版),2004,32(7):114-116,122. |
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| 作者姓名： | 马养民 傅建熙 |
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| 作者单位： | 西北农林科技大学,生命科学学院,陕西,杨凌,712100 |
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| 摘 要： | 用反-1-碘-3-三甲硅氧基-1-辛烯制备的锌试剂与2-(6-甲氧羰己基)-4-(2-四氢吡喃氧基)-环戊-2-烯酮,经1,4-加成反应合成了前列腺素E1甲酯,这表明用有机锌试剂通过1,4-加成反应合成前列腺素E类化合物是可行的。对其加成反应条件的分析显示,在CuCN作用下,其加成反应产率可提高约12%。
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| 关 键 词： | 有机锌 1 4-加成反应 前列腺素E1甲酯 有机合成 |
| 文章编号： | 1671-9387(2004)07-0114-03 |
| 收稿时间： | 2003/10/20 0:00:00 |
| 修稿时间： | 2003年10月20 |
Synthesis of prostaglandin E1 derivatives by 1,4-addition of an organozinc reagent |
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| MA Yang-min,FU Jian-xi.Synthesis of prostaglandin E1 derivatives by 1,4-addition of an organozinc reagent[J].Journal of Northwest Sci-Tech Univ of Agr and,2004,32(7):114-116,122. |
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| Authors: | MA Yang-min FU Jian-xi |
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| Institution: | (College of Life Sciences,Northwest Sci-Tech University of Agriculture and Forestry,Yangling,Shaanxi 712100,China) |
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| Abstract: | Preparation of prostaglandin E1 methyl ester was accomplished by 1,4-addition reaction of organozinc reagent made from 1-iodo-3-trimethysiloxy-1-octene with 2-(6-methoxylcarbonylhexyl)-4-(2-tetrahydro-pyranyloxy)-2-cyclopentenone.It indicates it is possible that prostaglandin E compounds could be synthesized with 1,4-addition reaction of organozinc agent.Under catalysis of CuCN,the yield could increase 12% in the 1,4-addition reaction. |
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