Lymphangiosarcoma with bone formation of the auricle in a dog |
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Authors: | Takayuki MINESHIGE Go SUGAHARA Tamio OHMURO Junichi KAMIIE Kinji SHIROTA |
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Institution: | 1)Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan;2)Ohmuro Veterinary Clinic, 4262–2 Oyamamachi, Machida, Tokyo 194–0212, Japan |
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Abstract: | A 12-year-old mixed-breed neutered female dog was referred with cutaneous tumors at the
left auricle. Histologically, the cutaneous tumor located in the dermis comprised numerous
clefts and cavernous channels lined by neoplastic endothelial cells with no erythrocytes.
Bone tissue without direct contact with neoplastic cells was seen in the well-developed
stromal connective tissue. The neoplastic endothelial cells exhibited mild to moderate
atypia. Immunohistochemically, neoplastic cells were positive for vimentin and negative
for cytokeratin and factor VIII-related antigen. Basement membrane around the neoplastic
lumens was positive for laminin in a linear or granular pattern. Ultrastructural
examination revealed discontinuous basement membrane beneath the tumor cells.
Histopathological features of this case were consistent with lymphangiosarcoma, and
stromal ossification was characteristic. |
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Keywords: | bone canine tumor pathology |
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